Articles related to RISK FACTORS

Systemic nicotinamide exposure was associated with a lower risk of conversion from ocular hypertension to primary open-angle glaucoma in a large real-world cohort. Patients receiving nicotinamide also had lower rates of topical therapy initiation and laser trabeculoplasty, although the study did not establish causality.

A randomized crossover trial of 108 habitual cannabis users found fewer premature atrial contractions on cannabis-use days than abstinence days. The short-term physiologic findings provide mechanistic insight but were not designed to evaluate long-term cardiovascular health outcomes.

Women presenting with acute myocardial infarction often report chest pain alongside additional symptoms such as dyspnea, nausea, fatigue, or jaw pain. Persistent diagnostic disparities continue to contribute to delays in recognition and treatment, particularly among younger women.

Two prospective cohorts found that metabolically unhealthy adults generally had higher dementia risk estimates regardless of obesity status. Metabolically healthy obesity was not associated with increased dementia risk in primary analyses, though findings varied across sensitivity analyses.

A large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.

A genome-wide analysis of more than 2.5 million adults identified 26 genetic regions associated with fibromyalgia risk. The findings support a neurologic biological basis for the condition, though they do not establish causality or create a diagnostic test.