Articles related to RISK FACTORS

In a propensity-matched analysis of more than 66,000 adults with hypertension, blood-brain barrier (BBB)-crossing antihypertensives were associated with a 16% lower dementia risk than BBB-non-crossing agents. The observational design prevents causal conclusions but adds to growing interest in whether some antihypertensives may influence cognitive outcomes beyond blood pressure control.

Self-reported cannabis use in the United States increased substantially between 2008 and 2022, with particularly pronounced growth in daily or near-daily consumption, while high-frequency alcohol use remained stable or declined during the same period.

Childhood ADHD was associated with higher rates of adult psychiatric and neurologic hospitalization in a Finnish birth cohort followed into adulthood, while most somatic health outcomes showed little evidence of a sustained association.

Daily consumption of sugar-sweetened beverages was associated with more than double the risk of gastric cancer in two large U.S. prospective cohorts, although the findings did not establish causality and require confirmation in additional studies.

A systematic review and meta-analysis of studies involving more than 230,000 adolescents found that greater social jet lag was associated with higher anxiety levels. The findings identified a consistent but small association and did not establish causality.

Systemic nicotinamide exposure was associated with a lower risk of conversion from ocular hypertension to primary open-angle glaucoma in a large real-world cohort. Patients receiving nicotinamide also had lower rates of topical therapy initiation and laser trabeculoplasty, although the study did not establish causality.