Articles related to PARKINSON'S DISEASE (PD)

Recordings from four Parkinson’s disease patients linked cuneiform and pedunculopontine nuclei activity to distinct phases of gait initiation. Freezing episodes were preceded by disrupted mesencephalic timing, though clinical translation remains early.

A large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.

Singer-songwriter Carly Simon described years of mobility limitations initially attributed to arthritis and joint replacement recovery before receiving a Parkinson’s disease diagnosis. Her experience highlights the diagnostic challenges created when evolving symptoms appear consistent with existing conditions.

Women with Parkinson disease exhibited greater Alzheimer-related amyloid plaque burden than men in an autopsy-confirmed cohort, although cognitive performance and dementia rates were similar between sexes.

Survey responses from 5,797 Fox Insight participants suggest sleep disturbances, autonomic dysfunction, and emotional changes preceded Parkinson’s disease diagnosis by more than a decade in a substantial proportion of respondents.

The LRRK2 inhibitor BIIB122 failed to slow disease progression versus placebo in 648 early-stage idiopathic Parkinson’s patients in the Phase 2b LUMA trial, leading Biogen and Denali to discontinue joint development.