Articles related to Pediatrics

A 21-element enhanced recovery protocol implemented across 18 US hospitals reduced inpatient opioid use by 56% in children undergoing GI surgery, with patients receiving 13 or more protocol elements averaging one fewer hospital day and half the complication risk.

A phase 3 randomized trial of 449 children with intracranial ependymoma found no significant event-free or overall survival benefit from adding maintenance chemotherapy after radiation, while molecular markers — particularly 1q gain and 6q loss — identified a high-risk posterior fossa subgroup with substantially worse outcomes.

The 2026 Surviving Sepsis Campaign pediatric guidelines issued 61 recommendations covering infection recognition, hemodynamics, ventilation, and long-term follow-up for children with sepsis or septic shock.

The FDA has approved an OTC switch for adapalene/benzoyl peroxide gel (Differin Epiduo) for patients 12 and older, expanding adolescent access to a fixed-dose retinoid combination without a prescription or clinical visit.

Approach-withdrawal behavioral patterns — including dysregulated negative affect and resistance to routine change — showed moderate associations with co-occurring internalizing and externalizing symptoms in a cohort of 280 children with autism.

The FDA approved inhaled insulin (Afrezza) for pediatric patients aged 6 and older with type 1 or type 2 diabetes, based on phase 3 trial data and long-term safety evidence from manufacturer-sponsored studies.