Articles related to NEONATOLOGY

Fetal macrosomia showed the strongest association with shoulder dystocia in a single-center case-control study of vaginal deliveries. Maternal overweight and diabetes also contributed to risk, while the low event count and retrospective design limit prediction.

Maternal anti-HPA-1a antibodies inhibited β3 integrin activation in laboratory models, with stronger functional inhibition in severe FNAIT cases. The findings suggest a mechanism beyond platelet clearance, but clinical validation remains necessary.

A case report identified high-titer anti-RhD IgG antibodies in maternal breast milk as a potential source of ongoing hemolysis in an infant with persistent HDFN after exchange transfusion. The finding highlights a possible mechanism for delayed disease persistence but requires further validation.

A large ECHO Cohort analysis associated several pregnancy urinary chemical biomarkers with modest shifts in gestational age and fetal growth measures. The observational findings did not establish causality.

FcγRIII-mediated macrophage phagocytosis emerges as the dominant mechanism of platelet destruction in FNAIT, suggesting targeted receptor blockade could offer a future therapeutic approach, though evidence remains preclinical.

Neonatal sepsis affects an estimated 22 per 1,000 live births globally and carries significant morbidity risk, with PA-authored CME examining risk stratification, diagnostic sequencing, and antimicrobial stewardship for the practicing provider.