Articles related to ANTIBIOTIC STEWARDSHIP

A multisociety consensus paper outlines hospital-level strategies to improve sepsis outcomes, emphasizing diagnostic stewardship, antimicrobial optimization, surveillance, infection prevention, and multidisciplinary infrastructure while prioritizing interventions judged most feasible and impactful for broad implementation.

Neonatal sepsis affects an estimated 22 per 1,000 live births globally and carries significant morbidity risk, with PA-authored CME examining risk stratification, diagnostic sequencing, and antimicrobial stewardship for the practicing provider.

A retrospective quasi-experimental study at St. Jude Children’s Research Hospital found that discontinuing empiric antibiotics within 72 hours of febrile neutropenia onset in clinically stable pediatric haploidentical HCT recipients reduced antibiotic exposure by a median of 8 days without significant differences in bloodstream infection, ICU admission, or mortality.

The use of a BD Vacutainer Z-tube, which costs approximately $0.25 to $0.50 per tube, represents a highly cost-effective intervention, preventing contamination and potentially saving nearly $11,000 per patient.

The 2026 Surviving Sepsis Campaign pediatric guidelines issued 61 recommendations covering infection recognition, hemodynamics, ventilation, and long-term follow-up for children with sepsis or septic shock.

Cotrimoxazole was associated with nearly twice the adverse event rate of fluoroquinolones in a retrospective study of 228 hospitalized men aged 75 or older with urinary tract infections, with acute kidney injury onset occurring at a median of six days post-initiation.