Articles related to Primary Care

This review outlines a practical approach to headache imaging, emphasizing that MRI is preferred over CT in most nonemergent settings, while contrast-enhanced MRI should be reserved for specific red-flag scenarios such as malignancy, immunosuppression, focal neurologic deficits, intracranial pressure disorders, infection, and trigeminal autonomic cephalalgias.

In a propensity-matched analysis of more than 66,000 adults with hypertension, blood-brain barrier (BBB)-crossing antihypertensives were associated with a 16% lower dementia risk than BBB-non-crossing agents. The observational design prevents causal conclusions but adds to growing interest in whether some antihypertensives may influence cognitive outcomes beyond blood pressure control.

The FDA authorized Avulux lenses as a nonpharmacologic adjunct for migraine-associated light sensitivity in patients aged 12 years and older, supported by clinical data showing reduced photophobia and exploratory signals of headache pain improvement in some users.

New consensus guidance favors once-daily oral iron and simplified IV administration, including fewer test doses, premedications, and infusion visits. Several recommendations depart from established protocols and require formulation-specific clinical judgment.

An editorial in Obesity highlights emerging evidence that GLP-1 receptor agonists may provide benefits beyond weight loss and glycemic control, while emphasizing unresolved questions regarding muscle preservation, nutritional status, and potential effects on substance use disorders.

Atorvastatin reduced major cardiovascular events among adults aged 70 years and older without known cardiovascular disease, diabetes, or dementia, but the benefit did not translate into a statistically significant improvement in disability-free survival over nearly six years of follow-up.