Articles related to Primary Care

Growing evidence suggests that exposure to natural environments may improve mood, attention, and selected cognitive functions, although the current literature remains insufficient to establish nature-based interventions as validated treatments for psychiatric disorders.

A systematic review of 12 studies found that vortioxetine consistently improved depressive symptoms in adults aged 65 years and older with major depressive disorder, but evidence for cognitive benefits remained mixed and largely confined to selected cognitive domains.

In a large multinational target-trial emulation, adults with serious mental illness who initiated GLP-1 receptor agonists experienced lower mortality and cardiovascular event rates than matched patients initiating SGLT2 inhibitors, though residual confounding remains a key limitation.

A single-day inhaled mebufotenin regimen produced rapid, sustained symptom reductions through day 8 in 10 patients with postpartum depression, but the uncontrolled trial provides an early clinical signal rather than comparative efficacy evidence.

Retinal imaging findings were associated with future atrial fibrillation diagnosis in two large UK datasets, with thinning of specific retinal nerve layers observed years before clinical detection. The study identified an early risk signal but did not establish causality or diagnostic utility.

Research examining cannabis and sexual function suggests possible associations with increased sexual frequency and orgasm satisfaction in some users, but findings remain inconsistent, largely observational, and influenced by dose, timing, formulation, and individual factors.