Articles related to Primary Care

A case report describes duodenal ulcer perforation in a woman receiving tirzepatide for weight loss, occurring shortly after dose escalation, though important confounders prevent conclusions about a causal drug relationship.

The FDA approved updated 2026-2027 formulations of Pfizer-BioNTech, Moderna, and Novavax COVID-19 vaccines targeting the XFG variant, aligning with advisory committee recommendations for the upcoming vaccination season.

Three adults receiving semaglutide or tirzepatide preserved or increased lean soft tissue while losing weight alongside resistance training and protein-focused diets, although the uncontrolled case series cannot determine which strategies produced these outcomes.

Experts reviewing available evidence suggest melatonin and magnesium may support sleep through different mechanisms, though benefits appear dependent on the underlying cause of sleep disturbance and overall evidence remains mixed, particularly for magnesium.

Semaglutide use before or during pregnancy was associated with greater gestational weight gain and several adverse outcomes in a retrospective cohort, although similar findings among former users complicate attribution to direct fetal exposure.

A large Danish registry study found that current use of oral menopausal hormone therapy was associated with increased venous thromboembolism risk, while transdermal therapy was not generally associated with higher thrombotic rates across regimens, doses, or durations.