Articles related to REAL-WORLD EVIDENCE

Semaglutide use before or during pregnancy was associated with greater gestational weight gain and several adverse outcomes in a retrospective cohort, although similar findings among former users complicate attribution to direct fetal exposure.

Semaglutide use was associated with lower psychiatric hospitalization and bipolar-relapse hospitalization risks among Swedish adults with bipolar disorder receiving antidiabetic medication, although the observational findings did not establish a therapeutic effect.

Invasive pneumococcal disease declined among US children across vaccine eras, but incidence remained substantially higher among those with chronic medical or immunocompromising conditions, with relative disparities widening over the 25-year claims-based study.

National Cancer Database data suggest that approximately half of prostate cancer focal therapy use from 2010 to 2023 occurred outside current guideline-supported settings, highlighting persistent gaps between clinical practice and available evidence.

Systemic nicotinamide exposure was associated with a lower risk of conversion from ocular hypertension to primary open-angle glaucoma in a large real-world cohort. Patients receiving nicotinamide also had lower rates of topical therapy initiation and laser trabeculoplasty, although the study did not establish causality.

A Veterans Health Administration analysis of 4,890 men with metastatic hormone-sensitive prostate cancer found that achieving a PSA level below 0.2 ng/mL within 9 months was associated with improved survival. The retrospective findings support a threshold previously identified in clinical trials.