Articles related to MATERNAL-FETAL MEDICINE

New consensus guidance favors once-daily oral iron and simplified IV administration, including fewer test doses, premedications, and infusion visits. Several recommendations depart from established protocols and require formulation-specific clinical judgment.

Maternal anti-HPA-1a antibodies inhibited β3 integrin activation in laboratory models, with stronger functional inhibition in severe FNAIT cases. The findings suggest a mechanism beyond platelet clearance, but clinical validation remains necessary.

Experts highlighted ongoing barriers and knowledge gaps affecting reproductive care for transgender and gender-diverse patients while outlining strategies to support pregnancy, postpartum care, and fertility discussions in affirming clinical environments.

ACOG has revised its approach to postmenopausal bleeding evaluation, recommending combined transvaginal ultrasonography and endometrial sampling for most patients at initial presentation. The update reflects rising endometrial cancer incidence, evolving evidence on cancer subtypes, and recognized limitations of ultrasound-only evaluation.

Female mice recovering from a single ketamine exposure demonstrated microglia-driven neuroplasticity through FKBP51 activation, while male mice did not. The findings identify a sex-specific biologic pathway in a preclinical model, and human relevance remains unconfirmed.

Pregnancy is well tolerated for many women with congenital heart disease, but outcomes vary substantially by underlying lesion and clinical characteristics. Current guidance emphasizes multidisciplinary counseling, structured risk assessment, and individualized management before conception.