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ACP Internist
A young woman with ulcerative colitis in remission on 5-ASA and azathioprine is seen for annual follow up. Immunizations are current and her depression and anxiety screens are negative. Review her current status and select the most important health maintenance screen.
Family Medicine/General Practice March 15th 2023
Journal of Clinical Oncology
As a TROP-2-directed antibody-drug conjugate with an SN-38 payload that has shown preliminary activity in metastatic urothelial carcinoma (mUC), sacituzumab govitecan (SG) – brand name Trodelvy –was evaluated and compared to current treatments to gauge whether SG objective response rates (ORRs) and median overall survival (OS) outperform the average of 10% ORR and 7 to 8 months OS.
Internal Medicine May 12th 2021
This new indication marks the second FDA approval for sacituzumab govitecan (Trodelvy, Immunomedics) and was based on the phase 2, single-arm TROPHY-U-01 main efficacy endpoints in objective response rate (ORR) and duration of response (DOR). With a relative 5-year survival rate of 5.5%, this is a significant advancement for patients with metastatic urothelial cancer (mUC), the most common type of bladder cancer.
Internal Medicine April 20th 2021