American Medical AssociationIntervention Reduces “Death Rattle” in End-of-Life Care

Publication: JAMADesign: Multicenter, randomized, double-blind, placebo-controlled trial performed in six hospices in the Netherlands of 162 patients with a life expectancy of three or more days. Administration of subcutaneous scopolamine butylbromide, 20 mg four times a day (n = 79) or placebo (n=78) in the 157 patients included in the primary analysis.Results: A death rattle occurred in […]

American College of PhysiciansPutting ACP’s Guidance on Shorter Courses for Antibiotics to Practice

In practice, “standard” duration of antibiotic therapy is often based on archaic studies. Newer evidence shows that shorter durations are often a better choice and that antibiotic resistance is more likely to develop with longer durations of therapy. Here are the recommendations applied to four commonly treated infections.

Mark Allen GroupHereditary Angioedema: An Update on Causes, Manifestations and Treatment

Can you differentiate between bradykinin-mediated angioedema and the more common histamine-mediated angioedema? How significant is a delayed diagnosis? Do you favor on-demand or preventative therapy? What is the recommended therapy? Access to specialist care and effective treatment in the past 10 years has improved the quality of life and reduced the mortality rate in patients […]

Haymarket MediaSwitching Antifibrotic Agents in Idiopathic Pulmonary Fibrosis (IPF)

Source: BMC Pulmonary MedicineFindings:  IPF patients who switched from one antifibrotic therapy to the alternative — whether from pirfenidone (Esbriet) to nintedanib (Ofev, Vargatef) or the other way around – had improved survival. This observation held true whether the reason for switch was disease progress or tolerance issues.Design: Multi-center retrospective cohort study; 262 patients

HealthgradesOldest and Youngest Doctors by Specialty

Which specialties will be most affected by changing age demographics among doctors? That’s the question the Association of American Medical Colleges (AAMC) asks in their latest survey of “Active Physicians by Age and Specialty”, which tallied up the results of 935,000 practicing physicians in the US. Where does your specialty fall on the list?

Haymarket MediaHypertension Journal Study: Evaluating ARBs vs. ACE Inhibitors Safety Outcomes

Findings: Primary outcomes included AMI, HF, stroke, and CVEs; 51 secondary and safety outcomes included angioedema, cough, syncope, and electrolyte abnormalities. ACE inhibitors were associated with a significantly increased risk of four secondary and safety outcomes compared with ARBs.Design: Multinational cohort study; Patients: ~2.3M ACE, ~674K ARB