Articles related to BLEEDING/BLOOD DISORDERS

Schistosomiasis should be considered in the differential diagnosis for patients presenting with rectal bleeding, particularly those with a history of freshwater exposure in endemic areas.

Pantoprazole demonstrated a significant reduction in upper gastrointestinal bleeding in mechanically ventilated ICU patients, offering a viable prophylactic option without impacting overall mortality rates.

Red-cell rosette formation in malaria may allow infected erythrocytes to evade splenic sequestration, posing challenges in treatment.

The study found that andexanet alfa significantly improves hemostatic efficacy in patients with intracerebral hemorrhage on factor Xa inhibitors but increases the risk of thrombotic events. These findings highlight the need for careful patient selection and monitoring when considering andexanet alfa in clinical practice.

The introduction of exa-cel as a gene-editing therapy marks a significant advance in treating hemoglobinopathies, offering new hope for patients with SCD and β-thalassemia. This treatment focuses on reactivating fetal hemoglobin to mitigate disease symptoms effectively.

In a recent study, 91% of patients with transfusion-dependent β-thalassemia achieved independence from transfusions following treatment with Exagamglogene Autotemcel.