Articles related to CLINICAL STUDY

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

PrimeC lowered neuron-derived TDP-43 levels in a Phase 2b ALS trial, with earlier analyses reporting functional and survival signals requiring confirmation in a planned pivotal study.

Six weeks of moderate sleep restriction increased weight, waist circumference, and sedentary time in adults with baseline adequate sleep and elevated cardiometabolic risk.

BCG vaccination increased immune responsiveness without inflammatory activation and shifted beta-amyloid patterns in a small mechanistic study of older adults.

Primary trabeculectomy reduced the rate of visual field loss by approximately 50% compared with a medications-first approach in newly diagnosed advanced open-angle glaucoma patients across a 5-year randomized trial, though standard quality-of-life instruments failed to detect that clinical benefit.

Multimodal MRI analysis identified two distinct migraine subgroups in a 111-patient cohort, with one cluster showing widespread cortical-subcortical connectivity changes and lower cortical volumes tied to greater disease burden and disability.