Articles related to CLINICAL STUDY
Perioperative Gabapentin Increases Adverse Clinical Events in Older Adults
According to the findings of the study, gabapentin should not be used on a regular basis. Individualization is required, based on the type of pain and the risk of delirium. If gabapentin is used to control postoperative pain, it must be closely monitored for the development of delirium. Low-dose opioids, along with nonpharmacologic pain management strategies such as postoperative physical therapy and mobilization, can still be used safely in the study population. Rather than relying on a single medication, a more holistic approach to postoperative pain control in the hospital setting is required.
Anesthesiology January 30th 2023
Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture
In this study, more than 12,000 patients 18 years and older with hospitalization for extremity fracture were randomized to LWMH or aspirin. Rates of DVT were 1.7% and 2.5%, respectively. PE, bleeding complications, and other SAEs were similar across groups. Death occurred in 0.73% and 0.78% respectively for LWMH and aspirin.
Hematology January 25th 2023
Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality
Greater adherence to a number of healthy eating patterns was linked to a lower risk of death in this cohort study, which included 44,085 men and 75,230 women from the Health Professionals Follow-Up Study (1986-2020) and the Nurses’ Health Study (1984-2020). These relationships held true for persons who were Hispanic, non-Hispanic Black, and non-Hispanic White, as well as for other racial and ethnic groupings.
All Specialties January 23rd 2023
Long COVID Outcomes at One Year After Mild SARS-CoV-2 Infection: Nationwide Cohort Study
This large cohort study evaluated the frequency of 70 long COVID outcomes in unvaccinated individuals with mild COVID infection matched to uninfected individuals and to vaccinated individuals. Anosmia and dysgeusia were the most frequently reported long COVID symptoms with the risk being dramatically increasing at 30 days to 6 months post infection and falling rapidly thereafter. Mild COVID generated an 85% increased risk of cognitive impairment an 80% increased risk of dyspnea and weakness and a nearly 50% increased risk for palpitations. The findings were consistent across all COVID variants and were more marked in adults than children. Vaccinated individuals with breakthrough infection had similar risk for all these outcomes with the exception of dyspnea, for which the risk was lower in vaccinated persons.
All Specialties January 18th 2023
The Anxiolytic and Antidepressant Effects of Transcranial Magnetic Stimulation in Patients with Anxious Depression
Clinically significant anxiolytic and antidepressant benefits were seen in anxious depression patients after TMS in all samples, with average reductions in GAD-7 and PHQ-9 scores of 50% or more. The PHQ-9 scores for both the anxious and nonanxious depression groups improved equally. The worried group, however, scored higher both at the beginning of the study and after TMS, leading to significantly lower categorical rates of response and remission in depressive symptoms. The shift in anxiety and depressive symptoms substantially correlated among individuals who had anxious depression.
Psychiatry January 18th 2023
Intravenous Thrombolysis in Patients with Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
The risk of symptomatic intracranial hemorrhage was lower among the 832 patients receiving direct oral anticoagulant treatment in this cohort study involving 33,207 patients with ischemic stroke who received intravenous thrombolysis at 64 centers in Europe, Asia, Australia, and New Zealand when compared to controls who received no anticoagulation. This outcome held true across subgroups and various selection methodologies.
Cardiology January 18th 2023