Articles related to CLINICAL STUDY

Among 29 CPAP-adherent men with severe obstructive sleep apnea, residual objective sleepiness was associated with white-matter diffusion differences, although the cross-sectional findings do not establish causality or support routine imaging.

Experts reviewing available evidence suggest melatonin and magnesium may support sleep through different mechanisms, though benefits appear dependent on the underlying cause of sleep disturbance and overall evidence remains mixed, particularly for magnesium.

A multicenter analysis of adults with biopsy-confirmed MASLD found that roughly one-quarter of cirrhosis cases developed before age 50, with type 2 diabetes and genetic susceptibility associated with earlier progression.

Intrauterine mepivacaine administered shortly before IUD placement reduced procedural pain and improved patient-reported experience in a randomized trial of women receiving smaller-diameter IUDs, although comparisons with other analgesic approaches remain limited.

Fetal macrosomia showed the strongest association with shoulder dystocia in a single-center case-control study of vaginal deliveries. Maternal overweight and diabetes also contributed to risk, while the low event count and retrospective design limit prediction.

Higher circulating xylitol levels were associated with increased rates of major adverse cardiovascular events in two large population cohorts, although the observational findings do not establish that xylitol directly causes cardiovascular harm.