Articles related to CLINICAL STUDY

A systematic review of 12 studies found that vortioxetine consistently improved depressive symptoms in adults aged 65 years and older with major depressive disorder, but evidence for cognitive benefits remained mixed and largely confined to selected cognitive domains.

Magnetoencephalography-based analysis of 263 patients with major depressive disorder identified five distinct brain connectivity profiles, each associated with differing symptom patterns, supporting the view that depression may encompass biologically heterogeneous subgroups rather than a single neurobiological condition.

Children exposed to maternal Tdap vaccination had lower pertussis toxin and diphtheria antibody concentrations at ages 3 and 4, but their responses matched controls after a preschool DTaP booster in this small Finnish follow-up.

Among 29 CPAP-adherent men with severe obstructive sleep apnea, residual objective sleepiness was associated with white-matter diffusion differences, although the cross-sectional findings do not establish causality or support routine imaging.

Experts reviewing available evidence suggest melatonin and magnesium may support sleep through different mechanisms, though benefits appear dependent on the underlying cause of sleep disturbance and overall evidence remains mixed, particularly for magnesium.

A multicenter analysis of adults with biopsy-confirmed MASLD found that roughly one-quarter of cirrhosis cases developed before age 50, with type 2 diabetes and genetic susceptibility associated with earlier progression.