Articles related to CLINICAL STUDY

Intrauterine mepivacaine administered shortly before IUD placement reduced procedural pain and improved patient-reported experience in a randomized trial of women receiving smaller-diameter IUDs, although comparisons with other analgesic approaches remain limited.

Fetal macrosomia showed the strongest association with shoulder dystocia in a single-center case-control study of vaginal deliveries. Maternal overweight and diabetes also contributed to risk, while the low event count and retrospective design limit prediction.

Higher circulating xylitol levels were associated with increased rates of major adverse cardiovascular events in two large population cohorts, although the observational findings do not establish that xylitol directly causes cardiovascular harm.

Targeted vitamin D supplementation successfully addressed widespread vitamin D insufficiency among post-myocardial infarction patients but did not significantly reduce major adverse cardiovascular events during more than four years of follow-up.

Adding coronary artery calcium scoring to PREVENT-ASCVD risk equations produced only modest improvements in 10-year ASCVD risk prediction among adults aged 45 to 79 years, with the greatest potential value observed in patients with borderline or intermediate estimated risk.

Daily consumption of 100% orange juice altered expression of genes involved in vascular and cardiovascular pathways in men with elevated waist circumference, although the six-week study did not demonstrate corresponding improvements in blood pressure or vascular function.