Articles related to QUALITY OF LIFE

A post hoc analysis of five brexpiprazole trials found improved functioning in adults with schizophrenia, including those with baseline hostility or agitation. The exploratory findings require interpretation alongside trial-design limitations and lack of multiplicity adjustment.

The NAUTILUS trial met its primary safety endpoint for responsive centromedian thalamic stimulation in drug-resistant idiopathic generalized epilepsy. The prespecified primary effectiveness endpoint was not significant, while post hoc and 18-month outcomes showed sustained seizure reductions.

In a 3-year randomized clinical trial, dialectical behavior therapy and schema therapy produced substantial improvements in borderline personality disorder severity. No statistically significant differences were observed between treatments on primary or secondary outcomes.

Fluvoxamine reduced fatigue and improved quality-of-life measures in adults with long COVID in a randomized placebo-controlled trial. The findings provide evidence for a potential therapy, although further research is needed to define optimal patient selection and treatment strategies.

Patients treated by advanced nurse practitioners in an Irish emergency department injuries service reported high levels of satisfaction and patient enablement. Communication quality was associated with both outcomes, although the study design did not establish causality.

An 8-week observational study of young adults with acne found significant improvements in both acne severity and dermatology-related quality of life. Improvements in clinical grading did not correlate with patient-reported quality-of-life gains, highlighting the multidimensional impact of acne.