Articles related to ANTIDEPRESSANTS

Physical symptoms following antidepressant cessation are generally transient and consistent with established discontinuation phenomena, while persistent or delayed symptoms remain difficult to explain pharmacodynamically and may involve psychiatric, psychological, or somatic contributors.

Emerging reports suggest some patients experience emotional blunting or reduced reward responsiveness after starting GLP-1 receptor agonists. Current evidence remains mixed, and available data have not established a causal relationship between GLP-1 therapy and diminished antidepressant response.

Fluvoxamine reduced fatigue and improved quality-of-life measures in adults with long COVID in a randomized placebo-controlled trial. The findings provide evidence for a potential therapy, although further research is needed to define optimal patient selection and treatment strategies.

Antidepressant prescription trajectories remained stable or absent for the majority of Swedish adults who continued working past age 65, with no worsening pattern observed around work exit in a 10-year longitudinal cohort of 32,849 participants.

Prenatal exposure to medications that inhibit sterol biosynthesis was associated with higher rates of autism spectrum disorder diagnosis in a 6.14-million-record retrospective analysis.

“Additional studies with larger samples and more detailed measures of ACE severity, frequency, and duration are essential.” – Ying Xiong, PhD, Karolinska Institutet, JAMA Network Open, 2026