Articles related to ANTIDEPRESSANTS

A new network meta-analysis reveals that high-dose psilocybin may be as effective as escitalopram for treating depressive symptoms, with a standardized mean difference of 0.31 compared to placebo in antidepressant trials.

Clinicians treating cancer and kidney disease patients prescribed antidepressants at rates similar to outpatient psychiatrists, highlighting the prevalence of depression management across specialties.

This target trial emulation study provides critical insights into weight change associated with eight first-line antidepressants, emphasizing the minimal weight gain with bupropion. Clinicians should integrate these findings into treatment decisions to address patient concerns about weight gain.

Clinicians should be vigilant about melatonin interactions with various medications such as antidepressants, blood thinners, and blood pressure drugs to ensure patient safety and effective treatment.

In this NEJM Double Take episode, experts discuss the critical role of neuroplasticity in depression and examine advanced treatment options for patients who do not respond to traditional therapies. Topics include the efficacy of ECT and TMS, as well as emerging evidence for ketamine, esketamine, and psilocybin.

Recent studies indicate that while ketamine and ECT are equally effective for treating MDD, ketamine did not prove non-inferior to ECT for MDEs. Both treatments have distinct side effect profiles that are critical for clinical decision-making.