Articles related to Internal Medicine

More than 4,100 laboratory-confirmed cyclospora infections have been reported across 41 states during a larger-than-usual US outbreak. Investigators continue to search for the source, and no food product has been definitively confirmed as responsible.

The Department of Defense announced annual testosterone-deficiency screening for service members aged 30 years and older, with optional testing for younger personnel. Clinicians have questioned whether broad population screening aligns with established diagnostic recommendations for hypogonadism.

Nearly 89% of U.S. ischemic heart disease deaths in 2023 were attributable to modifiable risk factors, according to Global Burden of Disease data. Mortality rates declined substantially since 1990, although deaths linked to elevated BMI and fasting glucose increased.

A prototype wearable ring continuously monitored multiple sweat biomarkers, including glucose and ketones, in healthy volunteers and individuals with type 1 diabetes. The device’s readings tracked established monitoring technologies, though larger validation studies remain necessary.

The FDA approved enlicitide (Lipfendra), the first oral PCSK9 inhibitor for lowering LDL cholesterol in adults with hypercholesterolemia. Approval was based on substantial LDL-C reductions, while cardiovascular outcomes data remain pending.

Filtered coffee consumption was associated with lower biological age-acceleration measures in nearly 50,000 UK Biobank participants, while instant coffee showed the opposite pattern. The cross-sectional analysis did not establish causality and remains hypothesis-generating.