Articles related to Internal Medicine

BCG vaccination increased immune responsiveness without inflammatory activation and shifted beta-amyloid patterns in a small mechanistic study of older adults.

The FDA has begun reviewing generic tirzepatide applications as global competition accelerates, despite US patent protections limiting near-term availability.

A multi-fiber formulation improved bowel frequency and stool consistency in adults with functional constipation in a short-term study evaluating combined fiber mechanisms.

A physician associate in an understaffed emergency department diagnosed a patient’s severe back pain as sciatica after a CT scan read as normal. Five days later, a different clinician identified a perirectal abscess that had already progressed to require multiple surgeries.

The FDA approved cefepime-zidebactam (Zaynich) for complicated UTI and pyelonephritis caused by susceptible gram-negative organisms. Approval followed phase 3 trial data showing higher rates of symptom and microbiologic resolution compared with meropenem in hospitalized adults.

A network meta-analysis of 32 randomized trials found long-term, high-dose vitamin D supplementation added to standard multiple sclerosis therapy reduced relapse risk and eased disability progression, while short-term use showed no significant effect.