Articles related to Internal Medicine

In a phase 3 trial of 214 adults with generalized anxiety disorder, a single dose of DT120 orally disintegrating tablets produced greater reductions in anxiety scores than placebo through 12 weeks. Full peer-reviewed data and longer-term results remain pending.

Emerging reports suggest some patients experience emotional blunting or reduced reward responsiveness after starting GLP-1 receptor agonists. Current evidence remains mixed, and available data have not established a causal relationship between GLP-1 therapy and diminished antidepressant response.

A randomized crossover trial of 108 habitual cannabis users found fewer premature atrial contractions on cannabis-use days than abstinence days. The short-term physiologic findings provide mechanistic insight but were not designed to evaluate long-term cardiovascular health outcomes.

Among more than 7,300 Swedish patients with Alzheimer’s disease and atrial fibrillation, NOAC use was associated with slower cognitive decline than warfarin or no anticoagulation. The observational findings did not establish causality but suggest potential differences in long-term cognitive outcomes.

The FDA approved Freenome’s SimpleScreen CRC blood test for colorectal cancer screening in average-risk adults. Clinical study results showed the test detected roughly 80% of colorectal cancers, though current guidelines continue to favor colonoscopy and stool-based screening options.

In an observational target trial emulation of patients with atrial fibrillation and mitral stenosis, DOACs were associated with higher 1-year stroke risk than warfarin. Bleeding and all-cause mortality risks did not differ between groups.