Articles related to Pediatric Neurology

Loss of the membrane-regulating protein NSF in dopamine D2 receptor-expressing neurons was associated with hyperactivity, impulsive behavior, and reduced striatal dopamine signaling in mice. The findings offer mechanistic insight into ADHD biology, although clinical relevance remains unproven.

The NAUTILUS trial met its primary safety endpoint for responsive centromedian thalamic stimulation in drug-resistant idiopathic generalized epilepsy. The prespecified primary effectiveness endpoint was not significant, while post hoc and 18-month outcomes showed sustained seizure reductions.

Genetic analyses of nearly 80,000 infants identified variants associated with toddler activity levels and other early behavioral traits. Several of these genetic signals overlapped with those previously linked to ADHD and autism, although the findings do not establish causality.

Prenatal fish oil supplementation was associated with small differences in cerebral blood flow and oxygen metabolism at age 10. Cognitive and psychopathology outcomes showed no significant association.

A joint epilepsy society position statement endorsed validated noninvasive seizure detection and alerting devices as part of individualized epilepsy care while emphasizing their strongest performance in tonic-clonic seizures and the absence of proven SUDEP prevention.

Youth with ADHD and comorbid ASD showed distinct medication patterns and greater psychiatric burden in a large EHR cohort. The observational findings did not establish causal treatment effects.