Articles related to CLINICAL CHALLENGE

A rare case of anti-ER5-mediated hemolytic disease of the fetus and newborn required international sourcing of ultrarare blood products and multiple intrauterine transfusions, highlighting the complexity of managing alloimmunization involving newly recognized high-incidence red blood cell antigens.

A young child with an inherited tumor-predisposition syndrome develops recurrent bilateral visual decline after completing first-line chemotherapy for a radiographically diagnosed optic pathway tumor, requiring reassessment of treatment urgency, systemic options, and surveillance.

A perimenopausal woman presenting with ST-segment elevation myocardial infarction was found to have both spontaneous coronary artery dissection and stress-induced cardiomyopathy, highlighting the diagnostic complexity and potential overlap of two uncommon causes of acute coronary syndrome in women.

A 55-year-old man developed progressive weakness, areflexia, and respiratory compromise after a fall, despite spinal imaging that initially appeared to explain his presentation.

A 16-year-old girl presented with acute aphasia and right-sided weakness consistent with a large-vessel stroke syndrome. Neuroimaging confirmed left middle cerebral artery occlusion, but the underlying etiology was not immediately apparent.

A young hyperopic patient developed prolonged acute angle-closure glaucoma after an initial misdiagnosis, leading clinicians to pursue an anatomy-based surgical approach when laser iridotomy alone failed to provide sustained pressure control.