Articles related to PAIN MANAGEMENT

Personalized models using wearable data forecast sedentary bouts in women with chronic pelvic pain, primarily endometriosis. Simpler models performed comparably to deep learning, but benefits from prediction-guided movement prompts remain untested.

A novel liposomal drug-delivery system prolonged tetrodotoxin nerve blockade to two to three weeks in rats, substantially exceeding currently available formulations. The findings highlight a potential strategy for sustained local anesthetic delivery, although clinical relevance remains unproven pending human validation.

A scoping review of 23 studies found that nurses most often implemented non-pharmacological postoperative pain interventions but participated less frequently in planning. Wide variation in interventions and outcomes limits conclusions about effectiveness or preferred approaches.

A genome-wide analysis of more than 2.5 million adults identified 26 genetic regions associated with fibromyalgia risk. The findings support a neurologic biological basis for the condition, though they do not establish causality or create a diagnostic test.

An observational study associated repeated gabapentin prescribing with higher rates of dementia and mild cognitive impairment, particularly among adults aged 18 to 64 years. Experts emphasized that the findings do not establish causality and should be interpreted cautiously.

A systematic review of 43 randomized controlled trials found high-certainty evidence that multiple CGRP-targeted therapies reduced monthly migraine headache days by approximately 2 days versus placebo in adults with chronic migraine.