Articles related to DRUG DISCOVERIES & DEVELOPMENT

A multiplexed cytokine and tumor-antigen mRNA immunotherapy produced durable tumor responses in mouse models of pancreatic ductal adenocarcinoma, with approximately half of treated animals remaining disease-free for up to one year, although clinical relevance remains unproven.

A novel small molecule, CN045, promoted oligodendrocyte maturation and modest remyelination in preclinical models of multiple sclerosis. The findings support an emerging strategy aimed at repairing damaged myelin, though clinical applicability remains unproven.

The FDA approved baxdrostat (Baxfendy), a selective oral aldosterone synthase inhibitor, as an adjunctive treatment for adults with hypertension uncontrolled on at least two existing antihypertensive agents, including a diuretic.

Researchers at the National University of Singapore developed a spinach-derived nanotechnology delivering plant photosynthetic machinery into corneal cells via eye drops, demonstrating reversal of corneal damage to near-healthy levels within five days in preclinical models of dry eye disease.

ALK7 gives pancreatic cancer cells both the engine to move and the tools to invade…But if we can inhibit ALK7 at the cancer’s earliest and most vulnerable stage, we might see better outcomes for patients.

In a significant advancement for knee osteoarthritis treatment, LEVI-04 demonstrated pain reduction in more than 50% of treated patients, with effects lasting through 20 weeks of study.