Articles related to TARGETED THERAPIES

Osimertinib significantly improved progression-free survival in patients with unresectable stage III EGFR-mutant NSCLC after chemoradiotherapy, with a hazard ratio of 0.16 compared to placebo.

The combination of ponatinib and blinatumomab demonstrated a 95% complete response rate and 91% 3-year overall survival rate in patients with Ph-positive ALL.

Lisocabtagene maraleucel offers a new treatment option for patients with CLL who have progressed on both BTK and BCL2 inhibitors, addressing an important unmet need in this patient population.

In a phase 3 trial comparing belzutifan to everolimus for advanced renal-cell carcinoma, belzutifan demonstrated a significant improvement in progression-free survival at 18 months (24.0% vs. 8.3%, P=0.002) and objective response rate (21.9% vs. 3.5%, P<0.001).

Sotorasib treatment in two patients with severe KRAS G12C-driven arteriovenous malformations resulted in rapid symptomatic improvement and sustained reduction in malformation volume over 24 months.

Researchers have identified insufficient activation of the aryl hydrocarbon receptor (AHR) pathway as a key driver in lupus pathogenesis, offering a new target for therapeutic intervention.