Articles related to LUPUS
Enzyme Tied to Inflammatory Immune Cell Activity in Lupus
Researchers discovered that inhibiting the activity of the fumarate hydratase enzyme in macrophages (a type of immune cell that plays a key role in inflammatory disorders) increased the cells’ production of interferon-beta. They also discovered that lupus patients’ macrophages have abnormally low levels of fumarate hydratase. These findings suggest that dysregulation of this enzyme may be a factor in the development of lupus, and that fumarate hydratase could be a potential therapeutic target.
Rheumatology March 23rd 2023
MKSAP Quiz: 2-week History of Fatigue, Poor Appetite, Arthralgia, and Rash
On exam, this 19-year-old woman has malar rash characterized by pink-violet papules and plaques with no other physical finding. ANA is positive and urinalysis is remarkable for 3+ blood and protein. What test is the most appropriate next step?
Dermatology January 25th 2023
Hydroxychloroquine Dose and Risk for Incident Retinopathy
Among more than 3,000 patients taking hydroxychloroquine, overall cumulative incidence for developing retinopathy were 2.5% and 8.6% at 10 and 15 years respectively. Incidence was strongly dose-related and most cases were mild.
Family Medicine/General Practice January 24th 2023