Articles related to Clinical Pharmacology

Nitrosamine impurities may increase cancer risk with long-term exposure above acceptable levels, though no immediate risk exists for patients currently taking this essential cardiovascular medication.

Excessive vitamin D absorption leads to calcium accumulation in bloodstream rather than bones, causing multi-system dysfunction from gastrointestinal irritation to cardiovascular complications.

Magnesium interactions span critical therapeutic classes from antibiotics to osteoporosis medications, requiring systematic identification during medication reconciliation and patient counseling protocols.

Multiple system failures – nurse transcription error creating lethal dose, pharmacist failure to question extraordinary opioid amount, and institutional non-disclosure to grieving family – created perfect storm for maximum legal liability.

First randomized evidence supporting feasibility of maintaining cardiac stability with carvedilol alone after systematic withdrawal of other heart failure medications in selected patients.

Multiple medication classes cause weight gain through distinct mechanisms including enhanced glucose uptake, metabolic slowing, increased appetite, and fluid retention, requiring tailored management approaches.