Articles related to Clinical Pharmacology

Lincosamides carried a 31-fold CDI risk and PPIs nearly doubled it in a Swedish analysis of 42,921 cases and 355,159 controls, with corticosteroids, antidepressants, and beta blockers also emerging as independent contributors.

Note that many questions remain after this trial returned results that are not unequivocally positive. The prespecified primary outcome was negative, which limits claims of efficacy and argues against overinterpreting the study as confirmatory evidence for psilocybin in treatment-resistant depression.

“The key word is association. This study does not establish causality. For absolute, catastrophic harm to an appropriately selected, monitored pain patient, the risk is small.” – Sean Mackey, MD, PhD, Chief of the Division of Stanford Pain Medicine

Although early stimulant exposure was not associated with increases in maternal or fetal risk, the study suggests that continuation of stimulants into the second and/or third trimester may increase some pregnancy complications.

Clinicians often are unaware that gabapentinoids can cause peripheral edema or even respiratory depression.

“People are more used to taking pills than they are taking injections” but “90% of a person’s weight is the result of what they eat. There are no magic solutions.”