Articles related to NEURODEVELOPMENTAL DISORDERS

Five years after participation in randomized trials, children with fetal alcohol spectrum disorder who received choline supplementation during early childhood demonstrated higher nonverbal IQ and working-memory performance than peers who received placebo, suggesting the intervention may influence long-term neurodevelopmental trajectories.

In a longitudinal analysis of more than 167,000 children in Wales, maternal depression was associated with higher rates of special educational needs and neurodevelopmental disorders. Additional risk observed among antidepressant-exposed pregnancies remained difficult to separate from underlying depression severity.

Loss of the membrane-regulating protein NSF in dopamine D2 receptor-expressing neurons was associated with hyperactivity, impulsive behavior, and reduced striatal dopamine signaling in mice. The findings offer mechanistic insight into ADHD biology, although clinical relevance remains unproven.

Analysis of genetic testing data from nearly 180,000 individuals with autism suggests that Phelan-McDermid syndrome may affect approximately 1 in 7,300 people. The findings indicate the condition may be substantially more common than previously estimated and highlight ongoing diagnostic gaps.

Genetic analyses of nearly 80,000 infants identified variants associated with toddler activity levels and other early behavioral traits. Several of these genetic signals overlapped with those previously linked to ADHD and autism, although the findings do not establish causality.

Single-nucleus multi-omics sequencing across genetically diverse ASD mouse models revealed convergent molecular and cellular changes in early brain development, despite distinct underlying mutations.