Articles related to MOTOR FUNCTION

Loss of the membrane-regulating protein NSF in dopamine D2 receptor-expressing neurons was associated with hyperactivity, impulsive behavior, and reduced striatal dopamine signaling in mice. The findings offer mechanistic insight into ADHD biology, although clinical relevance remains unproven.

Recordings from four Parkinson’s disease patients linked cuneiform and pedunculopontine nuclei activity to distinct phases of gait initiation. Freezing episodes were preceded by disrupted mesencephalic timing, though clinical translation remains early.

Stories from professional golfers with Parkinson’s illustrate how early motor symptoms disrupt precision, identity, and daily activities.

Repeated fecal transplants improved motor symptoms and constipation in early Parkinson’s, highlighting the gut microbiome as a potential therapeutic research pathway.

“A 65% reduction in the risk of death and a statistically significant extension in median survival of over 14 months represent a clinically meaningful benefit of notable magnitude in ALS.” — Alon Ben-Noon, CEO, Neurosense Therapeutics

Scatterplots were without evidence of an exposure threshold below which associations were absent, indicating linear dose-response relationships across all exposure levels.