Articles related to NEUROIMAGING

Individuals with psychiatric disorders demonstrated reduced flexibility in brain network reconfiguration across cognitive states in a transdiagnostic neuroimaging study. The findings linked dynamic brain patterns with symptom profiles but did not establish causality or clinical applicability.

A supervised random forest classifier trained on 330 features derived from nocturnal polysomnography achieved areas under the ROC curve approaching or exceeding 0.8 for distinguishing narcolepsy type 2, idiopathic hypersomnia, and controls in a national French reference database.

Multimodal MRI analysis identified two distinct migraine subgroups in a 111-patient cohort, with one cluster showing widespread cortical-subcortical connectivity changes and lower cortical volumes tied to greater disease burden and disability.

Brain-predicted age difference and socioeconomic status moderated the relationship between AD pathology markers and cognitive performance in a cross-sectional cohort of 621 cognitively unimpaired older adults.

A clinician review outlined how diagnostic confidence, staging, genetic risk, and imaging features inform patient selection for amyloid-targeting Alzheimer’s therapies.

Blarcamesine (Anavex 2-73), an investigational once-daily oral autophagy enhancer, showed sustained cognitive, functional, and brain volume benefits through nearly 3 years in a Phase 2b/3 trial and open-label extension presented at AD/PD 2026.