Articles related to CANCER PREVENTION

A growing body of observational evidence links coffee consumption with lower risks of several cancers, particularly hepatocellular and endometrial cancer, but experts caution that current data do not justify prescribing coffee as a cancer-prevention strategy.

A long-term analysis of nearly 160,000 US postmenopausal women found that brain and central nervous system cancer risk increased with higher residential radon concentrations, adding to limited evidence that radon may affect organs beyond the lung.

Daily low-dose endoxifen reduced mammographic breast density versus placebo in premenopausal women, with fewer tolerability concerns at 1 mg. Whether this surrogate response translates into lower breast cancer incidence remains unknown.

A phase 1 study of mKRAS-VAX in 20 patients at high risk for PDAC showed KRAS-specific T-cell responses in most participants. No high-grade adverse events occurred, but clinical prevention data remain early.

Low-dose (Z)-endoxifen significantly reduced mammographic breast density in premenopausal women while producing fewer treatment-related symptoms than expected with standard tamoxifen exposure. The phase II findings suggest a potential new prevention strategy, but effects on actual breast cancer incidence remain unknown.

GLP-1 receptor agonist use was associated with a 41% lower overall risk of obesity-related cancers in a retrospective cohort of more than 229,000 non-diabetic patients with obesity, with the largest risk reductions observed in endometrial, pancreatic, colorectal, and multiple myeloma.