Articles related to ALZHEIMER'S/DEMENTIA

Two prospective cohorts found that metabolically unhealthy adults generally had higher dementia risk estimates regardless of obesity status. Metabolically healthy obesity was not associated with increased dementia risk in primary analyses, though findings varied across sensitivity analyses.

A large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.

An observational study associated repeated gabapentin prescribing with higher rates of dementia and mild cognitive impairment, particularly among adults aged 18 to 64 years. Experts emphasized that the findings do not establish causality and should be interpreted cautiously.

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

Women with Parkinson disease exhibited greater Alzheimer-related amyloid plaque burden than men in an autopsy-confirmed cohort, although cognitive performance and dementia rates were similar between sexes.

Older adults’ real-time ratings of their mental sharpness closely tracked objective cognitive performance during everyday activities in a smartwatch-based study. The observational findings suggest potential utility for monitoring cognitive change but did not establish causality.