Articles related to ALZHEIMER'S/DEMENTIA

Use of estrogen-only hormone therapy in women over age 70 was associated with lower rates of dementia diagnoses and reduced Alzheimer-related pathology across large observational cohorts. The findings identify an association but do not establish a preventive effect against dementia.

Among adults with both sleep disturbances and mild cognitive impairment, self-reported vitamin D supplementation of at least 5,000 IU daily was associated with higher cognitive assessment scores in a small observational study, while lower doses showed no similar association.

A meta-analysis of seven studies found cannabinoid-based therapies were associated with lower agitation and neuropsychiatric symptom scores in patients with moderate to severe Alzheimer disease. Cognitive benefits were not consistently observed, and somnolence occurred more frequently with treatment.

Among more than 7,300 Swedish patients with Alzheimer’s disease and atrial fibrillation, NOAC use was associated with slower cognitive decline than warfarin or no anticoagulation. The observational findings did not establish causality but suggest potential differences in long-term cognitive outcomes.

Two prospective cohorts found that metabolically unhealthy adults generally had higher dementia risk estimates regardless of obesity status. Metabolically healthy obesity was not associated with increased dementia risk in primary analyses, though findings varied across sensitivity analyses.

A large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.