Articles related to BIOMARKERS

Loss of the membrane-regulating protein NSF in dopamine D2 receptor-expressing neurons was associated with hyperactivity, impulsive behavior, and reduced striatal dopamine signaling in mice. The findings offer mechanistic insight into ADHD biology, although clinical relevance remains unproven.

A prospective multicenter study of 970 adults with suspected mild traumatic brain injury (TBI) found that a rapid point-of-care blood test measuring GFAP and UCH-L1 achieved 96.5% sensitivity and 96.5% negative predictive value for detecting CT-positive intracranial injury, supporting its potential role in reducing unnecessary head CT imaging.

An experimental cell therapy that couples a patient’s red blood cells with myelin protein fragments was well tolerated in a 10-patient Phase 1b study and was associated with increases in regulatory T-cells and reductions in neurofilament light chain, a biomarker linked to nerve injury.

Artificial intelligence tools are increasingly being integrated into prostate cancer imaging, pathology, prognostication, and treatment planning. Although several platforms have demonstrated promising accuracy and workflow benefits, broad clinical adoption will require prospective validation, regulatory oversight, and careful implementation.

Researchers identified a metabolic pathway in which amino acid breakdown generates propionyl-CoA, sustaining cholesterol production and androgen signaling in prostate cancer models. The findings suggest a potential mechanism of hormone therapy resistance, though clinical relevance remains unproven.

A patient with advanced, treatment-resistant lung cancer experienced complete tumor disappearance after sodium selenite treatment and remained tumor-free for 10 years. The single case cannot establish efficacy, safety, or causality.