Articles related to TRAUMATIC BRAIN INJURY (TBI)

A prospective multicenter study of 970 adults with suspected mild traumatic brain injury (TBI) found that a rapid point-of-care blood test measuring GFAP and UCH-L1 achieved 96.5% sensitivity and 96.5% negative predictive value for detecting CT-positive intracranial injury, supporting its potential role in reducing unnecessary head CT imaging.

A large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

Although ketamine has historically been avoided due to concerns about increased intracranial pressure (ICP), more recent evidence has challenged this assumption.

Risk for CTE is increased with repetitive head impacts sustained during contact sports. However, prior studies have indicated that several neurodegenerative and cerebrovascular pathologies can result from repetitive head impacts.

The multidisciplinary guidelines introduce blood-based biomarkers as key diagnostic tools, potentially reducing unnecessary CT scans while improving outcome predictions.