Articles related to CLINICAL ASSESSMENT

A case report describes successful kidney transplantation in a highly sensitized patient whose probability of finding a compatible donor had been considered effectively zero. Treatment with teclistamab substantially reduced anti-HLA antibodies, enabling transplantation after prolonged wait-list status.

Two long-term proton pump inhibitor users presented with severe macrocytic anemia, markedly elevated LDH, and low haptoglobin suggestive of hemolysis. Further evaluation identified combined vitamin B12 and folate deficiency, highlighting a diagnostic mimic of true hemolytic anemia.

A retrospective study of 606 pediatric patients found serum specific IgE testing for allergic rhinitis was frequently negative in children younger than 3 years and became more informative with age. Findings may aid diagnostic decision-making, though prospective validation is needed.

ACOG has revised its approach to postmenopausal bleeding evaluation, recommending combined transvaginal ultrasonography and endometrial sampling for most patients at initial presentation. The update reflects rising endometrial cancer incidence, evolving evidence on cancer subtypes, and recognized limitations of ultrasound-only evaluation.

In a single-center cross-sectional study of 75 symptomatic patients, coronary artery calcium score and carotid intima-media thickness were associated with CT-derived CAD severity. The findings support risk-stratification interest but require prospective validation.

Singer-songwriter Carly Simon described years of mobility limitations initially attributed to arthritis and joint replacement recovery before receiving a Parkinson’s disease diagnosis. Her experience highlights the diagnostic challenges created when evolving symptoms appear consistent with existing conditions.