Articles related to EVIDENCE REVIEW

A network meta-analysis of 716 randomized trials and 159,362 participants found ARB-based regimens had the lowest rates of treatment discontinuation due to adverse effects, with the ARB-CCB combination ranking as the best-tolerated dual-drug option among antihypertensive regimens examined.

A meta-analysis of 232,655 out-of-hospital cardiac arrest cases found no statistically significant difference in favorable neurologic outcomes or survival to hospital discharge between bystander standard CPR with ventilation and chest compression-only CPR.

Each additional hour of daily digital screen exposure was associated with 21% higher odds of myopia in a 335,524-participant meta-analysis, with the steepest odds increase observed between 1 and 4 hours of daily exposure, though substantial heterogeneity and cross-sectional study designs precluded causal conclusions.

Peripapillary hyperreflective ovoid mass-like structures showed no significant correlation with intracranial pressure levels in a cross-sectional cohort of 54 patients with idiopathic intracranial hypertension, suggesting anatomic rather than pressure-driven origins.

A systematic review of 43 randomized controlled trials found high-certainty evidence that multiple CGRP-targeted therapies reduced monthly migraine headache days by approximately 2 days versus placebo in adults with chronic migraine.

In a 794-patient randomized trial, early-stage type 2 diabetes patients uncontrolled on metformin who received tirzepatide achieved nearly twice the HbA1c reduction of those on intensified conventional care at 2 years, and 60% reached normoglycemia (HbA1c <5.7%), compared to 24% in the ICC arm.