Articles related to AMD/MACULAR DEGENERATION

An early clinical experience report describes how one retina practice integrated photobiomodulation (PBM) for intermediate age-related macular degeneration, highlighting workflow considerations, patient selection challenges, reimbursement issues, and ongoing uncertainty regarding long-term benefit.

The FDA approved Lytenava as the first ophthalmic bevacizumab formulation for wet AMD. The decision moves bevacizumab beyond repackaged intravenous use, with launch logistics still pending.

Ocular Therapeutix announced FDA alignment on a planned fourth-quarter 2026 NDA submission for Axpaxli in wet AMD, based on SOL-1 phase 3 efficacy data and interim safety results from the ongoing SOL-R trial.

AREDS2 remains the evidence-based standard for AMD supplementation, but expanding understanding of complement dysregulation, mitochondrial dysfunction, and macular carotenoid biology has prompted discussion about whether a next-generation formulation could address pathways the current one does not target.

Erucamide, a naturally occurring lipid molecule, declined as photoreceptors deteriorated in preclinical retinal degeneration models, and restoring it via nanoparticle delivery slowed aspects of tissue breakdown without reversing damage.

A retinal specialist reviewing GLP-1 ocular safety evidence at the Retina World Congress concluded that current data do not support withholding therapy based on ocular risk alone, while recommending baseline retinal examination and closer monitoring in patients with preexisting severe diabetic retinopathy.