Wyanoke GroupAAP Updates Guidelines on Long-Term Care for Cancer Survivors

This is the third edition of the guidelines – the last coming in 2014 – providing a resource and guidance specifically for primary care practitioners about how to plan care for childhood cancer survivors. “A care plan just really encourages coordination, especially if a child has a very complicated post-cancer treatment history with a lot […]

Haymarket MediaLatest Cytogenetics of Pediatric Acute Myeloid Leukemia

About 75% to 80% of children with pediatric AML have clonal, acquired, somatic cytogenetic abnormalities (CAs) detected. Hematology Advisor briefs the information originally appearing in Genes, which reviews the current knowledge on evaluating pediatric patients based on cytogenetics and molecular subtypes to help match patients to risk-adapted therapies.

American Society of HematologyControlling CNS Relapse in Children with ALL Treated Without Cranial Irradiation

Publication: Blood Key Points: The authors identified the following four prognostic indicators that could help control CNS relapse in children with ALL. 1) Prephase dexamethasone treatment, 2) delayed intrathecal therapy, 3) use of total intravenous anesthesia during intrathecal therapy, and 4) flow cytometry examination of diagnostic CSF Design: 7,640 consecutive patients treated on Chinese Children’s […]

American Society of Clinical OncologyGenomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report from an International Consortium

Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent rhabdomyosarcoma – the most common soft tissue sarcoma of childhood – remains poor, and beyond PAX-FOX01 fusion status, no genomic markers are available for risk stratification. This international consortium study was designed to determine the incidence of driver mutations and their association […]

Millennium Medical PublishingConsiderations in the Management of Younger Patients With Colorectal Cancer

It is important for young people, caregivers, and healthcare providers to recognize possible symptoms of colorectal cancer (CRC) and arrange a colonoscopy or other tests when necessary. This article presents a thorough review of CRC and its impact on young patients, including a hypothesis for the increase of cases, screening recommendations, demographic features, symptoms, and […]

American Society of Clinical OncologyLong-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL

In this Original Report from the Journal of Clinical Oncology, the authors conducted a phase I trial of autologous CD19 CAR T cells in children and young adults (CAYAs) with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) to discover whether the role for allogeneic hematopoietic stem-cell transplant (alloHSCT) following CD19-CAR T-cell therapy can improve […]

American Society of HematologyHow I Treat Relapsed Acute Lymphoblastic Leukemia in the Pediatric Population

In the past decade, several promising immunotherapies have been developed, changing the treatment landscape for children with relapsed acute lymphoblastic leukemia (ALL). These advances in treatment offer real promise for less toxic and more effective therapy for children. In this article from Blood, the authors present several cases highlighting contemporary treatment decision-making.

Wyanoke GroupFour Institutions Join Pediatric Brain Tumor Consortium

The NCI sponsors and funds the consortium, a multidisciplinary cooperative research organization devoted to the study of correlative tumor biology and new therapies for children with primary central nervous system tumors. New members are chosen through a competitive process based on several characteristics, including clinical trial infrastructure and expertise in basic and translational science.