Articles related to PEDIATRIC CANCER
Low-Dose Chemo Noninferior to Standard-Dose Chemo in Children with AML
In a recent phase 3 trial, a low-dose chemotherapy regimen demonstrated noninferior efficacy to standard-dose regimens in pediatric AML patients, while significantly reducing non-hematologic toxicities, an important consideration in pediatric oncology.
Hematology January 22nd 2024
Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations
The phase 2 trial provides evidence that dabrafenib combined with trametinib could serve as a more effective and safer first-line treatment option for pediatric low-grade gliomas with BRAF V600 mutations. Evaluate the data to consider how this may influence your treatment protocols.
Oncology, Medical September 25th 2023
Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia
Discover how base editing via CRISPR-guided cytidine deamination could revolutionize CAR T-cell therapy for T-cell cancers, offering a promising approach to treating relapsed or refractory cases in pediatric patients.
Hematology/Oncology September 11th 2023
Cross-border ‘Twinning Programs’ May Reduce Survival Disparities for Childhood Leukemia
Bridging the Gap: Twinning Programs Improve Pediatric Cancer Survival Rates Across Borders In a world where a few miles can determine the fate of a child with cancer, twinning programs are making a significant difference. These initiatives, which pair hospitals across borders, are helping to bridge the survival gap in pediatric acute leukemia between high-income and lower-income countries. Key Points: “There’s no pediatric centers in many of the mountain west states. If your kid gets cancer in Wyoming, you gotta go to Utah or Colorado or Mayo in Minnesota. But here, there’s really nice evidence that providing the right protocols, training, staff, and more, we could do this in more places and improve outcomes without developing a new drug.” Gwen Nichols, chief medical officer of the Leukemia and Lymphoma Society
Hematology/Oncology June 12th 2023
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
Twenty-seven (27) children with heavily pretreated neuroblastoma (12 with refractory disease, 14 with relapsed disease, and one with a complete response at the end of first-line therapy) were enrolled in this academic, phase 1-2 clinical trial to test autologous, third-generation GD2-CAR T cells expressing the inducible caspase 9 suicide gene (GD2-CART01). The use of GD2-CART01 in the treatment of high-risk neuroblastoma was feasible and safe. Treatment-related toxic effects emerged, and the suicide gene was activated to control side effects. GD2-CART01 may have long-term antitumor activity.
Oncology, Medical April 10th 2023
Researchers Develop Liquid Biopsy Test for Pediatric Solid Tumors
The first version of the test, launched in November 2022, assesses chromosomal copy number changes in blood, cerebrospinal fluid, and the aqueous humor of the eye to aid in the clinical diagnosis of patients with solid tumors, brain tumors, and retinoblastoma, respectively. The next version of the clinical assay, which will be available in about six months, will detect mutations and gene fusions.
Oncology, Medical March 6th 2023