Articles related to GENOMICS

A phase 3 randomized trial of 449 children with intracranial ependymoma found no significant event-free or overall survival benefit from adding maintenance chemotherapy after radiation, while molecular markers — particularly 1q gain and 6q loss — identified a high-risk posterior fossa subgroup with substantially worse outcomes.

A DNA methylation–based IgE score measured in infancy was associated with recurrent wheezing by age 3 across three pediatric cohorts.

Among the people who ate the least meat, the ones with the APOE 3/4 and 4/4 variants had over twice the risk of dementia than those who did not have these variants.

“CHIP, especially non-DNMT3A CHIP, was independently associated with incident HF. Future research should explore the gene-specific mechanisms by which CHIP variants promote HF in humans.” — Study Authors, JAMA Cardiology

“Now that we have a treatment for genetic deafness, our hope is that this will spur universal genetic testing in all kids with hearing loss.” —Lawrence Lustig, MD, CHORD study investigator

“The variants we saw have been part of the human genome for a very long time, but the modern chemical environment is new, and we’re beginning to understand how these interactions might influence conditions like endometriosis.”