Articles related to PRECISION MEDICINE

Castalin can boost the effectiveness of CHK1 inhibitors, a class of drugs currently in phase 1 clinical trials. When tested in cellular models of triple-negative breast cancer, one of the most aggressive forms of the disease, Castalin was shown to enhance the action of these inhibitors.

These results suggest that PARP inhibition represents a potential treatment strategy in HRR-deficient advanced biliary tract cancer, including the potential platform to investigate novel combination treatment strategies as well as consideration for a more selective biomarker selection.

For every one-point increase in someone’s magnesium depletion score, their risk of depression rose by 13 percent… Lowering your magnesium depletion score, by improving your diet or addressing risk factors, may help prevent or even ease symptoms of depression.

“The test is designed to assess a patient’s individualized risk of sentinel lymph node positivity and recurrence or metastasis, integrating tumor biology with clinical and pathological features via a validated proprietary algorithm.”

The results of PROfound and PROpel underscore the importance of identifying the genomic characteristics of the patient and the cancer to guide the selection of the most appropriate treatment for a specific patient type.

The prevalence of HRR deficiencies has been found to be as high as 20% to 30% in patients with mCRPC, a significantly higher rate than that in patients with localized disease.