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A 55-year-old man with bilateral hand arthritis, ruddy complexion, and elevated transferrin saturation presents a diagnostic reasoning challenge with implications for screening, surveillance, and family testing.

A DNA methylation–based IgE score measured in infancy was associated with recurrent wheezing by age 3 across three pediatric cohorts.

A post hoc SURPASS-CVOT analysis associated tirzepatide with fewer six-component cardiorenal events than dulaglutide in patients with type 2 diabetes and established ASCVD.

ACC/AHA’s 2026 dyslipidemia guideline reintroduces LDL-C and non-HDL-C treatment goals, replaces Pooled Cohort Equations with PREVENT, and recommends one-time lipoprotein(a) measurement in all adults.

Extreme LDL-C in young patients with family history points toward familial hypercholesterolemia, a common genetic disorder that remains undiagnosed in 70% of cases.

Anonymous survey data from 2,689 young U.S. and Canadian men found 95% reported using at least one strategy to force sex with a nonconsenting woman, with self-reported success in roughly two-thirds of attempts.