Articles related to RISK STRATIFICATION

Individuals with psychiatric disorders demonstrated reduced flexibility in brain network reconfiguration across cognitive states in a transdiagnostic neuroimaging study. The findings linked dynamic brain patterns with symptom profiles but did not establish causality or clinical applicability.

Accumulating evidence suggests that initiating effective therapy earlier in Crohn’s disease may reduce bowel damage progression, hospitalizations, and surgery. Long-term follow-up from recent studies has strengthened interest in a therapeutic window during which disease modification may be achievable.

Pregnancy is well tolerated for many women with congenital heart disease, but outcomes vary substantially by underlying lesion and clinical characteristics. Current guidance emphasizes multidisciplinary counseling, structured risk assessment, and individualized management before conception.

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

A multivariable screening test detects 90% of clinically significant prostate cancers vs 74% with PSA alone, suggesting PSA thresholds may miss aggressive disease despite similar false-positive rates.

Premature menopause was linked to a 40% higher long-term risk of coronary heart disease in a pooled analysis of more than 10,000 women followed across six cohort studies.