In 2018, this previously high revenue-generating surgeon had a series of patient injuries and deaths resulting from his surgeries. He was removed from the surgery schedule following a whistleblower lawsuit.

HBCLs, not-otherwise specified (NOS), are rare and heterogeneous; other than having germinal center B-cell phenotype, and in up to 45%, a single-hit MYC rearrangement, they have no unifying immunophenotypic or cytogenetic characteristics. This review discusses the current clinicopathologic concept of HGBL, NOS, and looks at potential future taxonomy enrichments based on emerging molecular diagnostics.

Over a 4-year period, 500 patients were distributed equally between the two regimens. Two-year OS, relapse rates, and non-relapse mortality were similar between the two regiments, indicating that the busulfan regimen is non-inferior to the traditional TBI regimen.

This review summarizes the clinical presentation, workup, staging, and recent advancements in the treatment of PCNSL. Although treatment advances include the use of BTK inhibitors and immunomodulators, relapse is common and 5-year survival is 40% or lower. Thus, accurate early diagnosis and initiation of treatment is time sensitive for optimal neurologic recovery and disease control.

The hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone(hyper-CVAD) regimen has undergone many modifications to make administration more palatable and user-friendly for patients and physicians in community and academic settings, including refinements to avoid complications and reduce adverse events. Dr. Elias Jabbour of MD Anderson Cancer Center reviews a number of these modifications in this interview.

Using the most recent yearly figures from the Medscape 2022 Compensation Report and the typical hours spent as provided by the American Association of Medical Colleges, it is not surprising to see primary care specializations at the bottom of the list and specialists at the top. Anesthesiologists work lengthy shifts and earn a middle-of-the-road hourly rate. Dermatologists enjoy a healthy work-life balance and high earnings — it should come as no surprise that it’s one of the hardest fields to break into — but no one is surprised that PCPs are working hard for less money.