The constant presence of pain affects every aspect of daily living, with minimal friction causing severe blistering and requiring multiple daily wound care interventions across numerous body sites.

In a significant advancement for knee osteoarthritis treatment, LEVI-04 demonstrated pain reduction in more than 50% of treated patients, with effects lasting through 20 weeks of study.

Research demonstrates resistance training’s dual impact on cellular and hormonal mechanisms, showing improvements in mitochondrial efficiency and insulin sensitivity while reducing cortisol levels.

In pregnancy, asthma effects vary significantly: one-third of patients experience worsening symptoms, one-third improve, and one-third remain stable. Properly controlled asthma during pregnancy does not increase maternal or infant complications.

Long-term use of dopaminergic medications shows correlation with gradual RLS symptom deterioration, prompting a shift toward alpha-2-delta ligand calcium channel blockers as preferred pharmacological interventions.

N-nitroso-duloxetine poses increased cancer risk at higher concentrations and extended exposure periods, prompting FDA-mandated strict limits on nitrosamine levels in medications.