In a prospective cohort of more than 112,000 French adults, higher intake of several commonly used food preservatives was associated with increased risks of hypertension and cardiovascular disease, though the observational design cannot determine whether the additives themselves caused the observed outcomes.

Hypertension was associated with osteoarthritis in a Korean population analysis and accelerated cartilage deterioration through vasopressin signaling in mouse models, identifying a potential disease pathway whose therapeutic relevance in humans remains unproven.

The 2026 ESC heart failure guidelines redefine ejection-fraction phenotypes, formalize stages A through D, and broaden foundational therapy recommendations, including SGLT2 inhibitors and mineralocorticoid receptor antagonists across defined clinical settings.

In a secondary analysis of 371,038 U.S. adults, individuals reporting several cardiovascular disease (CVD) risk factors or established CVD reported less frequent whole-fruit consumption. The cross-sectional survey identified associations only and did not establish whether dietary behaviors preceded disease.

In a single-center randomized trial, mouth-dissolving clobazam and intranasal midazolam showed no statistically significant difference in clinical or electrographic seizure-termination time, supporting further study rather than establishing comparable efficacy.

In a retrospective memory-clinic cohort, greater MRI-derived brain age was associated with dementia progression among patients with subjective cognitive decline, although its incremental predictive value was limited and external validation remains necessary.