In this JAMA Original Investigation, the researchers studied 19,529 patients with Medicare coverage who initiated first systemic therapy for advanced non–small cell lung cancer (NSCLC) using 1 of 4 regimens of checkpoint inhibitor immunotherapy, cytotoxic chemotherapy, and combined chemoimmunotherapy. The goal? To gauge the uptake and effectiveness of immunotherapy among older patients outside clinical trials.
The study looked at cancer survivors aged 65 or older from the SEER-Medicare database; survivors were diagnosed with cancer between 2000 and 2012. Claims from 2007 to 2013 were used to estimate costs by cancer site, phases of care, and stage at diagnosis.