Following completion of this CME activity, health-system and specialty pharmacists should be better able to review the transmissibility and clinical severity associated with SARS-CoV-2 variants, analyze the efficacy of vaccines and boosters for the prevention of infection and severe disease caused by SARS-CoV-2 variants, analyze the efficacy of oral antivirals and remdesivir in light of emerging SARS-CoV-2 variants, and discuss the efficacy of monoclonal antibodies and convalescent plasma for prevention and treatment in the clinical context of current and evolving SARS-CoV-2 variants.