BloodMultisite 11-Year Experience of Less-Intensive vs. Intensive Therapies in Acute Myeloid Leukemia

Key Points: In two study cohorts, less-intensive therapies increased mortality in each of three risk groups defined by age, comorbidities, and cytogenetics. The differences became nonsignificant after accounting for physician perception of cure, emphasizing the need for a randomized trial.
Design: Multicenter retrospective cohort (1,292), 6 institutions, 2008-2012; prospective cohort (695), 13 institutions, 2013 – 2017
Connected Content: Fitness for Intensive Chemotherapy: A Continuing Conundrum