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Addiction ProfessionalNew Opioid Overdose Reversal Nasal Spray Receives FDA Approval

Opvee Reverses Remifentail-induced Respiratory Depression Within 5 Minutes


As the opioid crisis continues to evolve, so too does your arsenal of interventions. The FDA’s recent approval of Opvee, a nalmefene-based nasal spray, introduces a new tool for physicians in the fight against opioid overdose.

  • The FDA has approved Opvee, a new opioid overdose reversal nasal spray.
  • Opvee, developed by Opiant Pharmaceuticals, is designed for patients aged 12 and above.
  • The medication contains nalmefene, which reverses remifentail-induced respiratory depression within 2.5 to 5 minutes.
  • Opvee is the first nalmefene hydrochloride nasal spray approved by the FDA.
  • Some practitioners express concerns about Opvee’s longer acting period and the potential for severe withdrawal symptoms.
  • The FDA granted Opiant’s application for Opvee a priority review designation.
  • Development of Opvee was supported by up to $18.2 million in funding from BARDA and NIDA.