MDLinx‘Ozempic Tongue’ and Other Oral Side Effects Explained

Ozempic’s Unexpected Oral Effects: Taste Alterations and Implications for Patient Care

Recent research has illuminated a new side effect of Ozempic (semaglutide) dubbed “Ozempic tongue,” characterized by alterations in taste perception. This phenomenon, along with other oral side effects, has important implications for patient care and weight management strategies. Understanding these effects can help physicians better manage patients on semaglutide therapy and optimize treatment outcomes.

Key Points:

• “Ozempic tongue” refers to taste changes experienced by some patients taking semaglutide.
• Up to 6% of patients may experience dysgeusia as early as 2 weeks after starting semaglutide therapy.
• Semaglutide may enhance taste sensitivity, particularly to sweet flavors.
• The mechanism behind taste changes is not fully understood but may involve GLP-1 receptor signaling in taste buds.
• Other oral side effects include xerostomia, halitosis, and potential oral ulcers or mucosal irritation.
• Delayed gastric emptying caused by Ozempic can lead to acid reflux and an acidic taste in the mouth.
• Semaglutide may reduce tongue fat content, potentially improving obesity-associated sleep apnea.
• Physicians should monitor patients for taste changes and potential nutrient deficiencies.
• Hypoglycemia risk may increase if patients avoid carbohydrates due to taste aversions.
• Management strategies include using flavored mouthwashes, sugar-free gum, and maintaining good oral hygiene.
• Patients should be advised to consume a variety of foods with different flavors and textures.
• Staying hydrated is crucial, especially for patients experiencing xerostomia.
• To minimize halitosis and enamel erosion, patients should avoid late-night meals and acidic foods.
• Regular dental check-ups are important for patients on semaglutide therapy.

HCN Medical Memo
The discovery of “Ozempic tongue” and associated oral effects highlights the complex mechanisms by which semaglutide influences weight loss. Although these side effects may contribute to the medication’s efficacy, they also necessitate careful monitoring and patient education to ensure optimal outcomes and minimize potential complications.

More on Oral Health