MDLinxPatients are Complaining about ‘Ozempic Breasts’

Rapid Weight Loss from Semaglutide Use Linked to Breast Tissue Changes, Mirroring Post-Bariatric Surgery Effects

Semaglutide, a GLP-1 receptor agonist used for weight loss, has been associated with unexpected changes in breast tissue, dubbed “Ozempic breasts.” This phenomenon, characterized by breast ptosis or sagging, is thought to result from rapid adipose tissue reduction throughout the body, including the breasts. Although anecdotal reports are prevalent, definitive research on this specific effect is currently lacking. Understanding the potential for these changes and how to manage them is becoming increasingly important for healthcare providers as semaglutide use for weight loss continues to grow.

Key Points:

• “Ozempic breasts” refers to breast ptosis or sagging experienced by patients undergoing rapid weight loss with semaglutide use.
• Symptoms include breast sagging, loss of volume, and tenderness.
• The effect is likely due to rapid reduction of adipose tissue, a significant component of breast tissue.
• Higher risk groups for developing “Ozempic breasts” include women with larger breasts at baseline, patients with significant weight loss goals, and older patients with less skin elasticity.
• Patients with fibrocystic breasts may notice benign lumps becoming more apparent as surrounding tissue decreases.
• Breast changes are a result of rapid weight loss, not a direct effect of semaglutide itself.
• Adopting a gradual weight loss approach with dietary restrictions and exercise may mitigate symptoms.
• Recommendations for patients include:
  • Wearing a supportive bra throughout the day
  • Performing gentle breast massages to promote circulation
  • Targeting and building pectoralis and chest muscles
  • Maintaining a high-protein diet to support muscle mass and body composition
• Breast sagging may be temporary, lasting only while the patient takes the drug.
• Patients should maintain their desired weight for at least a year before considering breast-related interventions.
• For interventional management, referral to a qualified plastic surgeon may be appropriate for procedures such as mastopexy, breast augmentation, and lift with implants.

According to this article, the Journal of Obesity Surgery reports that women lose an average of 39.4% of their breast volume following major weight loss surgery.

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